diff --git a/packages/react-native/React/Fabric/Mounting/ComponentViews/View/RCTViewComponentView.mm b/packages/react-native/React/Fabric/Mounting/ComponentViews/View/RCTViewComponentView.mm
index 17945ce64e40..e2252c731e70 100644
--- a/packages/react-native/React/Fabric/Mounting/ComponentViews/View/RCTViewComponentView.mm
+++ b/packages/react-native/React/Fabric/Mounting/ComponentViews/View/RCTViewComponentView.mm
@@ -1890,7 +1890,13 @@ - (void)focus
 
 - (void)blur
 {
-  [[self window] resignFirstResponder];
+  // `NSWindow` does not implement `resignFirstResponder`; only NSResponder
+  // subclasses inherit it. Calling the selector on the window is a silent
+  // no-op, leaving programmatic `ref.blur()` from JS without effect. The
+  // correct AppKit equivalent is `makeFirstResponder:nil`, which clears
+  // the current first responder. Mirrors the working pattern at
+  // RCTTextInputComponentView.mm:995-997.
+  [[self window] makeFirstResponder:nil];
 }
 
 - (BOOL)needsPanelToBecomeKey
diff --git a/packages/react-native/React/Fabric/Mounting/ComponentViews/VirtualView/RCTVirtualViewComponentView.mm b/packages/react-native/React/Fabric/Mounting/ComponentViews/VirtualView/RCTVirtualViewComponentView.mm
index ba60397d95b7..adf21b150820 100644
--- a/packages/react-native/React/Fabric/Mounting/ComponentViews/VirtualView/RCTVirtualViewComponentView.mm
+++ b/packages/react-native/React/Fabric/Mounting/ComponentViews/VirtualView/RCTVirtualViewComponentView.mm
@@ -161,6 +161,38 @@ - (NSArray *)accessibilityChildren
   [self _unhideIfNeeded];
   return [super accessibilityChildren];
 }
+
+- (BOOL)acceptsFirstResponder
+{
+  // Mirror of the iOS `focusItemsInRect:` hook for keyboard / Tab
+  // navigation. AppKit queries `acceptsFirstResponder` while walking
+  // the responder chain to compute the next Tab target. If this view
+  // is hidden via the `hideOffscreenVirtualViewsOnIOS` optimization,
+  // we unhide here so a subsequent Tab landing actually finds a real
+  // view to focus.
+  //
+  // Caveat: a fully `hidden=YES` view is excluded from AppKit's
+  // responder chain at the parent level, so `acceptsFirstResponder`
+  // will not be queried until the view becomes visible. This override
+  // therefore only catches the "visible but flagged offscreen" case
+  // where `_unhideIfNeeded` is a fast no-op anyway. The complete fix
+  // for Tab-into-fully-hidden views requires switching the hiding
+  // strategy from `self.hidden = YES` to something that keeps the
+  // view in the responder chain (e.g. zero-alpha / out-of-bounds
+  // frame) — out of scope here; tracked as a follow-up.
+  [self _unhideIfNeeded];
+  return [super acceptsFirstResponder];
+}
+
+- (id)accessibilityHitTest:(NSPoint)point
+{
+  // VoiceOver cursor / pointer-hover-with-VoiceOver path. Same
+  // rationale as `accessibilityChildren` above: a hit-test that
+  // would land on a flagged-offscreen virtual view should unhide
+  // it so the AX tree has a real element to return.
+  [self _unhideIfNeeded];
+  return [super accessibilityHitTest:point];
+}
 #endif // macOS]
 
 - (void)prepareForRecycle
diff --git a/packages/react-native/React/Fabric/Mounting/RCTMountingManager.mm b/packages/react-native/React/Fabric/Mounting/RCTMountingManager.mm
index 4a517cdcf892..864cb579a9d7 100644
--- a/packages/react-native/React/Fabric/Mounting/RCTMountingManager.mm
+++ b/packages/react-native/React/Fabric/Mounting/RCTMountingManager.mm
@@ -346,7 +346,19 @@ - (void)synchronouslyDispatchAccessbilityEventOnUIThread:(ReactTag)reactTag even
     RCTUIView<RCTComponentViewProtocol> *componentView = [_componentViewRegistry findComponentViewWithTag:reactTag]; // [macOS]
 #if !TARGET_OS_OSX // [macOS]
     UIAccessibilityPostNotification(UIAccessibilityLayoutChangedNotification, componentView);
-#endif // [macOS]
+#else // [macOS
+    // Move first-responder to the component view and post the
+    // AppKit-equivalent accessibility notification so VoiceOver picks
+    // up the focus change. Without this branch the Fabric path for
+    // `AccessibilityInfo.setAccessibilityFocus(reactTag)` silently
+    // no-ops on macOS — the old-arch path in
+    // RCTAccessibilityManager.mm:setAccessibilityFocus: does the
+    // equivalent work, which we mirror here.
+    if (componentView != nil) {
+      [[componentView window] makeFirstResponder:componentView];
+      NSAccessibilityPostNotification(componentView, NSAccessibilityFocusedUIElementChangedNotification);
+    }
+#endif // macOS]
   }
 }