diff --git a/rules-tests/DeadCode/Rector/Assign/RemoveDoubleAssignRector/Fixture/skip_call_in_assign_target.php.inc b/rules-tests/DeadCode/Rector/Assign/RemoveDoubleAssignRector/Fixture/skip_call_in_assign_target.php.inc
new file mode 100644
index 00000000000..f164499bc13
--- /dev/null
+++ b/rules-tests/DeadCode/Rector/Assign/RemoveDoubleAssignRector/Fixture/skip_call_in_assign_target.php.inc
@@ -0,0 +1,13 @@
+<?php
+
+namespace Rector\Tests\DeadCode\Rector\Assign\RemoveDoubleAssignRector\Fixture;
+
+final class SkipCallInAssignTarget
+{
+    public function run($container)
+    {
+        $container->get(SomeService::class)->enabled = true;
+        $container->get(SomeService::class)->enabled = true;
+        $container->get(SomeService::class)->enabled = true;
+    }
+}
diff --git a/rules/DeadCode/Rector/Assign/RemoveDoubleAssignRector.php b/rules/DeadCode/Rector/Assign/RemoveDoubleAssignRector.php
index a9181c0417f..76534247fca 100644
--- a/rules/DeadCode/Rector/Assign/RemoveDoubleAssignRector.php
+++ b/rules/DeadCode/Rector/Assign/RemoveDoubleAssignRector.php
@@ -100,6 +100,15 @@ public function refactor(Node $node): ?Node
                 continue;
             }
 
+            // the assignment target itself may contain a call with side effects,
+            // e.g. $object->getService()->property = 1; — removing the first assign would skip the call
+            if ($this->betterNodeFinder->findFirst(
+                $stmt->expr->var,
+                fn (Node $subNode): bool => $this->sideEffectNodeDetector->detectCallExpr($subNode)
+            ) instanceof Node) {
+                continue;
+            }
+
             // next stmts can have side effect as well
             if (($nextAssign->var instanceof PropertyFetch || $nextAssign->var instanceof StaticPropertyFetch) && $this->sideEffectNodeDetector->detectCallExpr(
                 $nextAssign->expr